Multiple sequence alignment

Conservation symbol

*100% conserved
:>80% conserved
.>50% conserved

Mutation color

pinkPathogenic
cyanBenign
greyUnknown

SLC name Isoform
4P19B---------------------------------------------------------EYPVLQKILIGLILGAIVGLILGHY----GYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIH------LAVGGQQ---FQPHQAPPLVHILLDIVPTN---------------------------------------------------------------------PFG-ALANG-QVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAE-QGVHVV-GELAKVTAAVYVGLTLQ----ILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKE-MGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAK--------------------------------------------------------------------TE-----------------------
SLC1A1M-----------------------------------GKPARK------GCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHS---NLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGE---IARTGST---PEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEV--KPPSDPEMN----------------MTE--ESFTAVMTTAISKN-KTKEYKIVG-MYSDGINVLGLIVFCLVFGLVIG--------KMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIF-RKLGLYMATVLTGLAIHSIVILPLIYFIVVR---KNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAED------VTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQ-MDVS------SEVNIVNPFALESTILDNEDSDTKKSYVNG------GFAVDKSDTISF-TQTSQF-------------------
SLC1A31M-----------TKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGTILGFTLRPY----RMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKEN----MHREGKI---VRVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETL---------------VGAVINNVSEAMETLTRI---TEELVPVP-GSVNGVNALGLVVFSMCFGFVIG--------NMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTR---KNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDD------ITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKN-RDVEMGNSVIEENEMKKPY---QLIAQDNETEKPID-----------------------SETKM--------------------
SLC1A32M-----------TKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGTILGFTLRPY----RMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKEN----MHREGKI---VRVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETL---------------VGAVINNVSEAMETLTRI---TEELVPVP-GSVNGVNALGLVVFSMCFGFVIG--------NMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTR---KNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITIR---------------------------------------------------DRLRTTTNVLGDSLGAGIVEHLSRHELKN-RDVEMGNSVIEENEMKKPY---QLIAQDNETEKPID-----------------------SETKM--------------------
SLC1A6MSS---HGNSLFLRESGQRLGRVGWLQRLQESLQQRALRTRLRLQTMTLEHVLRFLRRNAFILLTVSAVVIGVSLAFALRPY----QLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLDNKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSKEG----LHREGRI---ETIPTADAFMDLIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLENVTRALGTLQEML-SFEETVPVP-GSANGINALGLVVFSVAFGLVIG--------GMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVTH---RNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTED------ITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELEL-QEAEL-----TLPSLGKPYK--SLMAQEKGASRGRG----------------------GNESAM--------------------
SLC1A7MV--------------------------------PHAILARG----------RDVCRRNGLLILSVLSVIVGCLLGFFLRTR----RLSPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAAQKET---TEQSGK----PIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAPEEAP--PRRILIYGVQEE-NGSHVQNFALDLTPPPEVV-----YKSEP-GTSDGMNVLGIVFFSATMGIMLG--------RMGDSGAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITK---KNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDD------ITLIIAVDWALDRFRTMINVLGDALAAGIMAHICRKDFARDTGTEK-----LLPCETKPVSLQEIVAAQQNGCVKSVAEASELTLGPTCPHHVPVQVEQ-DEELPAASLNHCTIQISE--LETNV
SLC1A21MAS---------TEGANNMPKQ------VEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLAS---PIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQ---LGPGKKN---DEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEAN----------------ATS--AVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTR---KNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDT-IDSQ------HRVHEDIEMTKTQSIYDDMKNHRESNSNQC------VYAAHNSVIVDE-CKVTLAANGKSADCSVEEEPWKREK
SLC1A22M------------------PKQ------VEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLAS---PIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQ---LGPGKKN---DEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEAN----------------ATS--AVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMG--------KMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTR---KNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTED------ISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDT-IDSQ------HRVHEDIEMTKTQSIYDDMKNHRESNSNQC------VYAAHNSVIVDE-CKVTLAANGKSADCSVEEEPWKREK
SLC1A4M--EKSNETNGYLDSAQAGPAAGPGAP---------GTAAGR------ARRCAGFLRRQALVLLTVSGVLAGAGLGAALRGL----SLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVV--------TQN----------------SSS--GNV-------------THEKIPIG-TEIEGMNILGLVLFALVLGVALK--------KLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTR---KNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHD------LPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKK-GEQEL-------AEVKVEA--IPNCKSEEETSPLVTHQNP------AGPVASAPELES-KESVL--------------------
SLC1A5MVADPPRDSKG---LAAAEPTANGGLA--LASIEDQGAAAGG--YCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINAS-VGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYE----------ERN----------------ITG------------------TRVKVPVG-QEVEGMNILGLVVFAIVFGVALR--------KLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTR---KNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDH------ISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPEL-------IQVKSELPLDPLPVPTEEGNPLLKHYRG--------PAGDATVASE-KESVM--------------------
Conservation:                  .                 . .               : .: ...::: .:. *  .:  ::       ..   . .. ::*..:.*:* :..:*:...*:..* :.:: ...:..* .:..::. *:..*. .:.... .:.** .        .   ..      .  .:..:::.::.:* *:: :.: .  : .  .    .   . .                 ..   ..     .       . .  ...     *.:.*::..*   .* ...        ...  .  : .::..:::. :..*  :::*.*.*: .*:.::: :..:  .   .*..: ..:. *: .:. ..::*.** .:.   ::*. *. : ..:..:*..:.**:.*** :..:.:*:.:.:.:..:*.**.***.****:*::...*:.***: :. .*  :::.*:. :::..:.:::..: .:..:. ..:..::::. :      . :. :::: .*: :* .**.**..::::. ...  ..    . .             .      .                                   .