Home ＞ Activity report ＞Prof. Dr. Altenbach gave a lecture at Ochanomizu University.
Prof. Dr. Altenbach gave a lecture at Ochanomizu University.
| October 7, 2010 Prof. Dr. Altenbach gave a lecture at Ochanomizu University. |
 
Prof. Dr. Altenbach of Wuppertal University, Germany gave a lecture
entitled "Sugar Analogues as Enzyme Inhibitors, Signaling Molecules
and Potential Drugs" at Ochanomizu University, Science Building No.1
on October 7th, 2010.Abstract: Carba- and azasugars, sugar analogues, where the ring oxygen of a furanose or a pyranose is replaced by a CH2-group or a N-atom, are widespread natural products and have attracted a lot of interest due to their broad spectrum of biological activities, including antibiotic, antiviral and cancerostatic properties. The biological activity is mainly due to their ability to mimic specific sugars and being effective glycosidase inhibitors of the corresponding carbohydrates. In continuation of the search for flexible synthetic routes to aza- and carbasugar systems very efficient approaches will be described for both classes of compounds using easily accessible chiral building blocks. The great potential of approaches via enantiomerically pure central building blocks will be demonstrated in short syntheses of five-and six-membered imino-sugars with different configuration and substitution pattern and in six membered carbasugars. New examples of the successful application of this strategy will be described. |