Secondary Structure Prediction by Chou-Fasman (ver. 1.1)

Predict locations of alpha-helix and beta-strand from amino acid sequence using Chou and Fasman method.
  1. Input the amino acid sequence by one of the following ways;

    1. Upload the amino acid sequence file (flat format):
    2. Paste the amino acid sequence in the box:



Sample input file is here.

The method is implemented in this server based on the description in the following book;
Peter Prevelige, Jr. and Gerald D. Fasman (1989) Chapter 9: Chou-Fasman Prediction of the Secondary Structure of Proteins: The Chou-Fasman-Prevelige Algorithm. in Prediction of Protein Structure and the Principles of Protein Conformation (edited by Gerald D. Fasman), Plenum, New York, pp.391-416 (ISBN 0306431319).

The Principle in Chou and Fasman method

Secondary structure prediction method by Chou and Fasman (CF) is one of the oldest and simplest method. The method was originally presented in 1974 and later improved in 1977, 1978, 1979, 1985 and 1989.

CF depends on observed frequency of types of amino acid residues in alpha-elix, beta strand, beta turn, and other structures in protein three-dimensional structures. ....


update: 21st, Feb., 2009
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